New insights into the “invariant rate of the aging hypothesis”

New research has found new evidence of our inevitable death.

A study led by Fernando Corcello of the University of Southern Denmark and Susan Alberts of Duke University in North Carolina, including researchers from 42 institutions in 14 countries, provides new insights into the aging theory “the invariant rate of the aging hypothesis.” To do. All species have a relatively constant aging rate.

“Human death is inevitable. Ultimately, people die of aging, regardless of vitamin intake, environmental health, or physical activity,” says Fernando Corcello.

He is an expert in applying statistics and mathematics to population biology and is an associate professor in the Faculty of Mathematics and Computer Science at the University of Southern Denmark.

“By combining a wealth of unpresented data and comparing the birth and death patterns of a population of nine humans with information from 30 populations of non-human primates such as gorillas, chimpanzees, and baboons, We were able to shed light on the immutable aging hypothesis, in the wild and at the zoo, “said Fernando Corcello.

To explore this hypothesis, researchers analyzed the relationship between life expectancy (which is the average age at which an individual dies in the population) and life expectancy.

Their results show that the longer life expectancy, the greater the equality of life expectancy. As a result, life equality is very high when most individuals in the population tend to die at about the same age, as seen in modern Japan and Sweden. This is the 70’s and 80’s. However, in the 1800s, life expectancy was very low due to the low concentration of deaths and short life expectancy in the same country.

“Life expectancy has increased dramatically and is still increasing in many parts of the world, but not because we slowed down the rate of aging, because more and more infants, Children and adolescents survive, which raises life expectancy, “says Fernando Corcello.

Previous studies by some of the authors of the study have revealed a surprising regularity between life expectancy and life expectancy equality among populations, from pre-industrial European countries, hunter-gatherers to modern industrialized countries.

However, by investigating these patterns among our closest relatives, this study shows that this pattern may be universal among primates, but produces it. It provides a unique insight into the mechanism of doing so.

“We have observed that not only humans, but also other primate species exposed to different environments, have succeeded in living longer by reducing child mortality. Relationships only hold if we reduce premature mortality, not by lowering aging, “says Fernando Corcello.

Using statistics and mathematics, the authors show that even small changes in the rate of aging will make a baboon population, for example, behave demographically as a chimpanzee or human population.

“Not everything is lost,” says Fernando Corcello. “Since medicine has progressed at an unprecedented pace, science may probably succeed in reducing what was impossible to evolve: the rate of aging.”

Reference: F. Corcello, JM Ablt, EA Archie, C. Bosch, T. Breuer, FA Campos, A. Collins, DA Conde, M. Code “Longevity of Primates and” Immutable Aging Rate “Hypothesis”, C. Crockford, ME Thompson, LM Fedigan, C. Fichtel, M. Groenenberg, C. Hobaiter, PM Kappeler, RR Lawler, RJ Lewis, ZP Machanda, ML Manguette, MN Muller, C. Packer, RJ Parnell, S. Perry, AE Pusey, MM Robbins, RM Seyfarth, JB Silk, J. Staerk, TS Stoinski, EJ Stokes, KB Strier, SC Strum, J. Tung, F. Villavicencio, RM Wittig, RW Wrangham, K. Zuberbühler, JW Vaupel, SC Albert, June 16, 2021 Nature Communications..
DOI: 0.1038 / s41467-021-23894-3

This work was supported by NIA P01AG031719 and was provided with additional support by the Max Planck Institute for Demographics and the Duke University Institute for Population. New insights into the “invariant rate of the aging hypothesis”

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