Car raised $ 46.5 million Move the CD47x4-1BB, which targets the fusion protein, deep into the clinic. Due to the size of the funding, Kahr Arms has sufficient funding to acquire TIGITx PD-1 assets through IND-enabled research.
Jerusalem-based Kahr will fund the early development of the lead drug DSP107, which is designed to block immunosuppressive signals and activate T cells by binding to CD47 and 4-1BB. Raised $ 18 million last year. DSP107 is currently in Phase 1/2 clinical trials in patients with advanced solid tumors, either as a single agent or in combination with Roche’s Tecentric.
Kahr recognizes the specific potential of DSP107 as monotherapy and combination therapy in patients with non-small cell lung cancer, which is the focus of Part 2 of the clinical trial. Biotechnology will also begin Phase 1/2 clinical trials in acute myeloid leukemia, myelodysplastic syndrome, and T-cell lymphoproliferative disorders in the coming months. This test tests DSP107 in combination with the active ingredients azacitidine and venetoclax of Vidaza and Venclexta, respectively.
An expanded syndicate of investors has come together to fund their work. The round was led by aMoon with the support of new investors BVF Partners, DAFNA Capital Management, Peregrine Ventures, Shavit Capital and Cancer Focus Fund. Existing backers, including Flerie Invest, are back in the latest round.
The expansion of the syndicate and the call for funding will allow Kahr to begin a new trial of DSP107 while directing other candidates to the clinic. Kahr’s preclinical pipeline includes DSP502, a TIGITxPD-1 fusion protein.
GlaxoSmithKline has solidified TIGIT’s status this week as a bright red immuno-oncology target. Agree to pay iTeos Therapeutics will prepaid $ 625 million for Phase 1 candidate rights. Companies such as Merck and Roche are studying the use of anti-TIGIT antibodies in combination with PD-1 / L1 checkpoint inhibitors. In DSP502, Kahr has a single molecule designed to hit both TIGIT and PD-1.
DSP502, along with another preclinical asset, DSP216, will be researched for IND. Another candidate is the LILRB2xSIRPa fusion protein. LILRB2 may function as an immune checkpoint for macrophages and other bone marrow cells. The molecular SIRPa element is designed to block CD47s, thereby suppressing the “don’t eat me” signal.
https://www.fiercebiotech.com/biotech/kahr-reels-47m-to-fund-cd47-trial-work-tigit-prospect Kahr has raised $ 47 million to fund the CD47 trial and is working on the TIGIT outlook