Ingestion of fish oil may reduce antibiotic resistance

For the first time, Australian scientists have identified the association of regular fish oil with the role of “super bugs” in destroying the ability of “super bugs” to resist antibiotics.

Discoveries guided by Flinders University And just published in an international journal mBioWe have found that the antibacterial activity of fish oil fatty acids can prove to be a simple and safe dietary supplement for people to take with antibiotics to make their fight against infections more effective.

“Importantly, our study shows that major intracellular antibiotic resistance mechanisms can be adversely affected by ingestion of omega-3 fatty acids,” says Flinders University’s Bacterial Host Adaptation. Dr. Bart Eijkelkamp, ​​a microbiologist who leads the lab, said.

“Experimental and complementary supercomputer modeling has found that these fatty acids in fish oil make bacteria more sensitive to a variety of common antibiotics.”

“This gap in harmful bacterial armor is an important step in combating the growing number of superbugs developing multidrug resistance to antibiotics,” said co-author Megan Omara. Australian National University..

Bart Eikelkamp

Dr. Bart Eijkelkamp (left) and researchers Felice Adams and Maoge Zang of the Institute for Bacterial Host Adaptation at Flinders University, South Australia.Credits: Flinders University

This study is essential in the field of infections caused by bacteria such as Acinetobacter baumannii, the leading pathogen of nosocomial infections with unprecedented levels of antibiotic resistance worldwide.

“With the advent of superbug, we were able to show that greedy bacteria could not distinguish between” good “hosts and bad host fatty acids and consumed all of them during infection,” said another co-author, Felise. Dr. Adams says. Flinders University.

“Our research has shown that fish oil fatty acids become part of the bacterial membrane, increasing the permeability of the invading bacterial membrane and making it more susceptible to the antibiotics used to attack it. . “

“Acinetobacter baumannii is known to be one of the most notorious multidrug-resistant pathogens in the world, but it is not well understood how it responds to host-mediated stress.”

“These studies provide new insights into the potential benefits of omega 3 supplements, especially against bacterial infections during antibiotic treatment,” said Anton Pereg, director of the Infectious Diseases Division at Alfred Hospital in Melbourne. Stated.


Felise G Adams, Claudia Trappetti, Jack K Waters, Maoge Zang, Erin B Brazel, James C Paton, Marten F Snel, Bart A Eijkelkamp, ​​June 9, 2021 mBio..
DOI: 10.1128 / mBio.00928-21

“Membrane composition defines the spatial composition and function of Acinetobacter baumani’s major drug excretion system.” Written by: Maoge Zang, Hugo MacDermott-Opeskin, Felise G Adams, Varsha Naidu, Jack K Waters, Ashley B Carey, Alex Ashenden, Kimberley T McLean, Erin B. Brazel, The Han Jean, Alessandra Panitza, Claudia Trapetti, James C. Paton, Anton Y. Peleg, Ingo Caper, Ian T. Paulsen, Karl A. Hassan, Megan L. Omara, Bart Eikerkamp, ​​June 9, 2020 mBio..
DOI: 10.1128 / mBio.01070-21

Two research publications feature collaborators from ANU, Macquarie University, University of Adelaide, Monash University, University of Newcastle, and SA HMRI, funding NHMRC project grants 1140554 to MLO and 1159752. And support cooperation. Ingestion of fish oil may reduce antibiotic resistance

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