High-value pleiotropic genes for developing multiple stress-tolerant biofortified crops for 21st-century challenges
Abad LR, D’Urzo MP, Liu D, Narasimhan ML, Reuveni M, Zhu JK et al. (1996) Antifungal activity of tobacco osmotin has specificity and involves plasma membrane permeabilization. Plant Sci 118(1):11–23
Abdallah NA, Prakash CS, McHughen AG (2015) Genome editing for crop improvement: challenges and opportunities. GM Crops Food 6(4):183–205
Aggarwal S, Kumar A, Bhati KK, Kaur G, Shukla V, Tiwari S et al. (2018) RNAi-mediated downregulation of inositol pentakisphosphate kinase (IPK1) in wheat grains decreases phytic acid levels and increases Fe and Zn accumulation. Front Plant Sci 9:259
Alexandratos N, Bruinsma J (2012) World Agriculture towards 2030/2050: The 2012 Revision. ESA Working Paper No. 12-03, FAO, Rome.
Ali N, Paul S, Gayen D, Sarkar SN, Datta K, Datta SK (2013) Development of low phytate rice by RNAi mediated seed-specific silencing of inositol 1, 3, 4, 5, 6-pentakisphosphate 2-kinase gene (IPK1). PloS ONE 8(7):e68161
Anil Kumar S, Hima Kumari P, Shravan Kumar G, Mohanalatha C, Kavi Kishor P (2015) Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin. Front Plant Sci 6:163
Annon A, Rathore K, Crosby K (2014) Overexpression of a tobacco osmotin gene in carrot (Daucus carota L.) enhances drought tolerance. Vitr Cell Dev Biol-Plant 50(3):299–306
Arrivault S, Senger T, Krämer U (2006) The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply. Plant J 46(5):861–879
Asano T, Hayashi N, Kobayashi M, Aoki N, Miyao A, Mitsuhara I et al. (2012) A rice calcium-dependent protein kinase OsCPK12 oppositely modulates salt-stress tolerance and blast disease resistance. Plant J 69(1):26–36
Assunção A, Martins PDC, De Folter S, Vooijs R, Schat H, Aarts M (2001) Elevated expression of metal transporter genes in three accessions of the metal hyperaccumulator Thlaspi caerulescens. Plant, Cell Environ 24(2):217–226
Badawi GH, Yamauchi Y, Shimada E, Sasaki R, Kawano N, Tanaka K et al. (2004) Enhanced tolerance to salt stress and water deficit by overexpressing superoxide dismutase in tobacco (Nicotiana tabacum) chloroplasts. Plant Sci 166(4):919–928
Barthakur S, Babu V, Bansa K (2001) Over-expression of osmotin induces proline accumulation and confers tolerance to osmotic stress in transgenic tobacco. J Plant Biochem Biotechnol 10(1):31–37
Bashir K, Inoue H, Nagasaka S, Takahashi M, Nakanishi H, Mori S et al. (2006) Cloning and characterization of deoxymugineic acid synthase genes from graminaceous plants. J Biol Chem 281(43):32395–32402
Bol J, Linthorst H, Cornelissen B (1990) Plant pathogenesis-related proteins induced by virus infection. Annu Rev Phytopathol 28(1):113–138
Bouis HE (2000) Enrichment of food staples through plant breeding: a new strategy for fighting micronutrient malnutrition. Nutrition 16(7-8):701–704
Bouis HE, Chassy BM, Ochanda JO (2003) 2. Genetically modified food crops and their contribution to human nutrition and food quality. Trends Food Sci Technol 14(5-8):191–209
Briat J-F, Lobreaux S, Grignon N, Vansuyt G (1999) Regulation of plant ferritin synthesis: how and why. Cell Mol Life Sci CMLS 56(1):155–166
Brinch-Pedersen H, Sørensen LD, Holm PB (2002) Engineering crop plants: getting a handle on phosphate. Trends Plant Sci 7(3):118–125
Broadley MR, White PJ, Hammond JP, Zelko I, Lux A (2007) Zinc in plants. N. Phytologist 173(4):677–702
Bughio N, Yamaguchi H, Nishizawa NK, Nakanishi H, Mori S(2002) Cloning an iron‐regulated metal transporter from rice J Exp Bot 53(374):1677–1682
Cai G, Wang G, Wang L, Pan J, Liu Y, Li D (2014) ZmMKK1, a novel group A mitogen-activated protein kinase kinase gene in maize, conferred chilling stress tolerance and was involved in pathogen defense in transgenic tobacco. Plant Sci 214:57–73
Caimi PG, McCole LM, Klein TM, Kerr PS (1996) Fructan accumulation and sucrose metabolism in transgenic maize endosperm expressing a Bacillus amyloliquefaciens SacB gene. Plant Physiol 110(2):355–363
Cao S, Du X-H, Li L-H, Liu Y-D, Zhang L, Pan X et al. (2017) Overexpression of Populus tomentosa cytosolic ascorbate peroxidase enhances abiotic stress tolerance in tobacco plants. Russian J Plant Physiol 64(2):224–234
Chen M, Wang Q-Y, Cheng X-G, Xu Z-S, Li L-C, Ye X-G et al. (2007) GmDREB2, a soybean DRE-binding transcription factor, conferred drought and high-salt tolerance in transgenic plants. Biochem Biophys Res Commun 353(2):299–305
Chen W, Chen P, Liu D, Kynast R, Friebe B, Velazhahan R et al. (1999) Development of wheat scab symptoms is delayed in transgenic wheat plants that constitutively express a rice thaumatin-like protein gene. Theor Appl Genet 99(5):755–760
Chen Z, Young TE, Ling J, Chang S-C, Gallie DR (2003) Increasing vitamin C content of plants through enhanced ascorbate recycling. Proc Natl Acad Sci 100(6):3525–3530
Cheng M-C, Liao P-M, Kuo W-W, Lin T-P (2013) The Arabidopsis ETHYLENE RESPONSE FACTOR1 regulates abiotic stress-responsive gene expression by binding to different cis-acting elements in response to different stress signals. Plant Physiol 162(3):1566–1582
Chowdhury S, Basu A, Kundu S (2017) Overexpression of a new osmotin-like protein gene (SindOLP) confers tolerance against biotic and abiotic stresses in sesame. Front Plant Sci 8:410
Chu H-H, Chiecko J, Punshon T, Lanzirotti A, Lahner B, Salt DE et al. (2010) Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures. Plant Physiol 154(1):197–210
Chun HJ, Park HC, Koo SC, Lee JH, Park CY, Choi MS et al. (2012) Constitutive expression of mammalian nitric oxide synthase in tobacco plants triggers disease resistance to pathogens. Mol Cells 34(5):463–471
Cohen CK, Garvin DF, Kochian LV (2004) Kinetic properties of a micronutrient transporter from Pisum sativum indicate a primary function in Fe uptake from the soil. Planta 218(5):784–792
Colangelo EP, Guerinot ML (2006) Put the metal to the petal: metal uptake and transport throughout plants. Curr Opin Plant Biol 9(3):322–330
D’angeli S, Altamura M (2007) Osmotin induces cold protection in olive trees by affecting programmed cell death and cytoskeleton organization. Planta 225(5):1147–1163
Das M, Chauhan H, Chhibbar A, Haq QMR, Khurana P (2011) High-efficiency transformation and selective tolerance against biotic and abiotic stress in mulberry, Morus indica cv. K2, by constitutive and inducible expression of tobacco osmotin. Transgenic Res. 20(2):231–246
Datta K, Baisakh N, Ganguly M, Krishnan S, Yamaguchi Shinozaki K, Datta SK (2012) Overexpression of Arabidopsis and rice stress genes’ inducible transcription factor confers drought and salinity tolerance to rice. Plant Biotechnol J 10(5):579–586
Davuluri GR, Van Tuinen A, Fraser PD, Manfredonia A, Newman R, Burgess D et al. (2005) Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes. Nat Biotechnol 23(7):890–895
Degryse F, Verma V, Smolders E (2008) Mobilization of Cu and Zn by root exudates of dicotyledonous plants in resin-buffered solutions and in soil. Plant Soil 306(1):69–84
Demidchik V, Bowen HC, Maathuis FJ, Shabala SN, Tester MA, White PJ et al. (2002) Arabidopsis thaliana root non-selective cation channels mediate calcium uptake and are involved in growth. Plant J 32(5):799–808
Deokar AA, Kondawar V, Kohli D, Aslam M, Jain PK, Karuppayil SM et al. (2015) The CarERF genes in chickpea (Cicer arietinum L.) and the identification of CarERF116 as abiotic stress responsive transcription factor. Funct Integr Genomics 15(1):27–46
Devappa RK, Makkar HP, Becker K (2012) Localisation of antinutrients and qualitative identification of toxic components in Jatropha curcas seed. J Sci Food Agric 92(7):1519–1525
del Pozo T, Cambiazo V, González M (2010) Gene expression profiling analysis of copper homeostasis in Arabidopsis thaliana. Biochem Biophys Res. Commun 393(2):248–252
DiDonato Jr RJ, Roberts LA, Sanderson T, Eisley RB, Walker EL (2004) Arabidopsis Yellow Stripe-Like2 (YSL2): a metal-regulated gene encoding a plasma membrane transporter of nicotianamine–metal complexes. Plant J 39(3):403–414
Dietz K-J, Vogel MO, Viehhauser A (2010) AP2/EREBP transcription factors are part of gene regulatory networks and integrate metabolic, hormonal and environmental signals in stress acclimation and retrograde signalling. Protoplasma 245(1):3–14
Dong N, Liu X, Lu Y, Du L, Xu H, Liu H et al. (2010) Overexpression of TaPIEP1, a pathogen-induced ERF gene of wheat, confers host-enhanced resistance to fungal pathogen Bipolaris sorokiniana. Funct Integr Genomics 10(2):215–226
Dudley AM, Janse DM, Tanay A, Shamir R, Church GM (2005) A global view of pleiotropy and phenotypically derived gene function in yeast. Mol Syst Biol 1(1):2005.0001
Durrett TP, Gassmann W, Rogers EE (2007) The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation. Plant Physiol 144(1):197–205
Duy D, Wanner G, Meda AR, von Wirén N, Soll JR, Philippar K (2007) PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport. Plant Cell 19(3):986–1006
Eckhardt U, Marques AM, Buckhout TJ (2001) Two iron-regulated cation transporters from tomato complement metal uptake-deficient yeast mutants. Plant Mol Biol 45(4):437–448
Eltayeb AE, Kawano N, Badawi GH, Kaminaka H, Sanekata T, Shibahara T et al. (2007) Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses. Planta 225(5):1255–1264
Fagoaga C, Rodrigo I, Conejero V, Hinarejos C, Tuset JJ, Arnau J et al. (2001) Increased tolerance to Phytophthora citrophthora in transgenic orange plants constitutively expressing a tomato pathogenesis related protein PR-5. Mol Breed 7(2):175–185
Fairbanks DJ, Rytting B (2001) Mendelian controversies: a botanical and historical review. Am J Bot 88(5):737–752
Firbank LG, Attwood S, Eory V, Gadanakis Y, Lynch JM, Sonnino R et al. (2018) Grand challenges in sustainable intensification and ecosystem services. Front Sust Food Syst 2:7
Food Security Information Network (FSIN) Global Report on Food Crises 2020: Joint Analysis for Better Decisions World Food Programme, Rome, Italy (2020)
Frossard E, Bucher M, Mächler F, Mozafar A, Hurrell R (2000) Potential for increasing the content and bioavailability of Fe, Zn and Ca in plants for human nutrition. J Sci Food Agric 80(7):861–879
Gaber A, Yoshimura K, Yamamoto T, Yabuta Y, Takeda T, Miyasaka H et al. (2006) Glutathione peroxidase-like protein of Synechocystis PCC 6803 confers tolerance to oxidative and environmental stresses in transgenic Arabidopsis. Physiol Plant 128(2):251–262
Gao F, Yao H, Zhao H, Zhou J, Luo X, Huang Y et al. (2016) Tartary buckwheat FtMYB10 encodes an R2R3-MYB transcription factor that acts as a novel negative regulator of salt and drought response in transgenic Arabidopsis. Plant Physiol Biochem 109:387–396
Gao S, Zhang H, Tian Y, Li F, Zhang Z, Lu X et al. (2008) Expression of TERF1 in rice regulates expression of stress-responsive genes and enhances tolerance to drought and high-salinity. Plant Cell Rep 27(11):1787–1795
Genc Y, Humphries JM, Lyons GH, Graham RD (2005) Exploiting genotypic variation in plant nutrient accumulation to alleviate micronutrient deficiency in populations. J Trace Elem Med Biol 18(4):319–324
Gilmour SJ, Sebolt AM, Salazar MP, Everard JD, Thomashow MF (2000) Overexpression of the Arabidopsis CBF3 transcriptional activator mimics multiple biochemical changes associated with cold acclimation. Plant Physiol 124(4):1854–1865
Goel D, Singh A, Yadav V, Babbar S, Bansal K (2010) Overexpression of osmotin gene confers tolerance to salt and drought stresses in transgenic tomato (Solanum lycopersicum L.). Protoplasma 245(1):133–141
Goto F, Yoshihara T, Saiki H (2000) Iron accumulation and enhanced growth in transgenic lettuce plants expressing the iron-binding protein ferritin. Theor Appl Genet 100(5):658–664
Graham RD, Welch RM, Bouis HE (2001) Addressing micronutrient malnutrition through enhancing the nutritional quality of staple foods: principles, perspectives and knowledge gaps. Advances in Agronomy 70:77–142. https://doi.org/10.1016/S0065-2113(01)70004-1
Graham RD, Welch RM, Saunders DA, Ortiz-Monasterio I, Bouis HE, Bonierbale M et al. (2007) Nutritious subsistence food systems. Adv Agron 92:1–74
Green LS, Rogers EE (2004) FRD3 controls iron localization in Arabidopsis. Plant Physiol 136(1):2523–2531
Gross J, Stein RJ, Fett-Neto AG, Fett JP (2003) Iron homeostasis related genes in rice. Genet Mol Biol 26:477–497
Grotz N, Guerinot ML (2006) Molecular aspects of Cu, Fe and Zn homeostasis in plants. Biochim et Biophys Acta 1763(7):595–608
Guo W-J, Bundithya W, Goldsbrough PB (2003) Characterization of the Arabidopsis metallothionein gene family: tissue-specific expression and induction during senescence and in response to copper N. Phytol 159(2):369–381
Hao D, Ohme-Takagi M, Sarai A (1998) Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant. J Biol Chem 273(41):26857–26861
Hao Z, Wang X, Zong Y, Wen S, Cheng Y, Li H (2019) Enzymatic activity and functional analysis under multiple abiotic stress conditions of a dehydroascorbate reductase gene derived from Liriodendron Chinense. Environ Exp Bot 167:103850
Hasanuzzaman M, Hossain MA, da Silva JAT, Fujita M (2012) Plant response and tolerance to abiotic oxidative stress: antioxidant defense is a key factor Crop stress and its management: perspectives and strategies. Springer, Dordrecht, 261–315
Haydon MJ, Cobbett CS (2007) Transporters of ligands for essential metal ions in plants. N. Phytologist 174(3):499–506
He L, Yang X, Wang L, Zhu L, Zhou T, Deng J et al. (2013) Molecular cloning and functional characterization of a novel cotton CBL-interacting protein kinase gene (GhCIPK6) reveals its involvement in multiple abiotic stress tolerance in transgenic plants. Biochem Biophys Res Commun 435(2):209–215
He X, Zhang J (2006) Toward a molecular understanding of pleiotropy. Genetics 173(4):1885–1891
Hodgkin J (2002) Seven types of pleiotropy. Int J Dev Biol 42(3):501–505
Hoffland E, Wei C, Wissuwa M (2006) Organic anion exudation by lowland rice (Oryza sativa L.) at zinc and phosphorus deficiency. Plant Soil 283(1):155–162
Hossain MA, Teixeira da Silva J, Fujita M (2011) Glyoxalase system and reactive oxygen species detoxification system in plant abiotic stress response and tolerance: an intimate relationship. Abiot Stress/book 1:235–266
Hsieh T-H, Lee J-T, Charng Y-Y, Chan M-T (2002) Tomato plants ectopically expressing Arabidopsis CBF1 show enhanced resistance to water deficit stress. Plant Physiol 130(2):618–626
Husaini AM (2014) Challenges of climate change: Omics-based biology of saffron plants and organic agricultural biotechnology for sustainable saffron production. GM Crops Food 5(2):97–105
Husaini AM, Abdin MZ (2008a) Development of transgenic strawberry (Fragaria x ananassa Duch.) plants tolerant to salt stress. Plant Sci 174(4):446–455
Husaini AM, Abdin MZ (2008b) Overexpression of tobacco osmotin gene leads to salt stress tolerance in strawberry (Fragaria× ananassa Duch.) plants. Indian J Biotechnol 7:465–471
Husaini AM, Rafiqi AM (2012) Role of osmotin in strawberry improvement. Plant Mol Biol Rep 30(5):1055–1064
Husaini AM, Tuteja N (2013) Biotech crops: Imperative for achieving the Millenium Development Goals and sustainability of agriculture in the climate change era. GM Crops Food 4(1):1–9
Husaini AM, Sohail M (2018) Time to redefine organic agriculture: Can’t GM crops be certified as organics? Front Plant Sci 9:423
Husaini AM, Rashid Z, Mir RU, Aquil B (2011) Approaches for gene targeting and targeted gene expression in plants. GM Crops 2(3):150–162
Husaini AM, Kamili AN, Wani M, Teixeira da Silva J, Bhat G (2010) Sustainable saffron (Crocus sativus Kashmirianus) production: technological and policy interventions for Kashmir. Funct Plant Sci Biotechnol 4(2):116–127
Husaini AM, Abdin MZ, Khan S, Xu YW, Aquil S, Anis M (2012) Modifying strawberry for better adaptability to adverse impact of climate change. Curr Sci 102(12):1660–1673
Husaini AM and Xu YW (2016) Challenges of Climate Change to Strawberry Cultivation: Uncertainty and Beyond. In: Strawberry- Growth, Development and Diseases (Eds. Husaini AM and Neri D), CABI, UK, pp.262–287
Ibrahim S, Saleem B, Rehman N, Zafar SA, Naeem MK, Khan MR (2021) CRISPR/Cas9 mediated disruption of Inositol Pentakisphosphate 2-Kinase 1 (TaIPK1) reduces phytic acid and improves iron and zinc accumulation in wheat grains. J Adv Res. https://doi.org/10.1016/j.jare.2021.07.006
Ishimaru Y, Suzuki M, Kobayashi T, Takahashi M, Nakanishi H, Mori S et al. (2005) OsZIP4, a novel zinc-regulated zinc transporter in rice. J Exp Bot 56(422):3207–3214
Ishimaru Y, Suzuki M, Tsukamoto T, Suzuki K, Nakazono M, Kobayashi T et al. (2006) Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+. Plant J 45(3):335–346
Ismail AM, Heuer S, Thomson MJ, Wissuwa M (2007) Genetic and genomic approaches to develop rice germplasm for problem soils. Plant Mol Biol 65(4):547–570
Ito Y, Katsura K, Maruyama K, Taji T, Kobayashi M, Seki M et al. (2006) Functional analysis of rice DREB1/CBF-type transcription factors involved in cold-responsive gene expression in transgenic rice. Plant Cell Physiol 47(1):141–153
Jaglo-Ottosen KR, Gilmour SJ, Zarka DG, Schabenberger O, Thomashow MF (1998) Arabidopsis CBF1 overexpression induces COR genes and enhances freezing tolerance. Science 280(5360):104–106
Jean ML, Schikora A, Mari S, Briat JF, Curie C (2005) A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading. Plant J 44(5):769–782
Jia H, Hao L, Guo X, Liu S, Yan Y, Guo X (2016) A Raf-like MAPKKK gene, GhRaf19, negatively regulates tolerance to drought and salt and positively regulates resistance to cold stress by modulating reactive oxygen species in cotton. Plant Sci 252:267–281
Jung C, Seo JS, Han SW, Koo YJ, Kim CH, Song SI et al. (2008) Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis. Plant Physiol 146(2):623–635
Kapoor D, Singh S, Kumar V, Romero R, Prasad R, Singh J (2019) Antioxidant enzymes regulation in plants in reference to reactive oxygen species (ROS) and reactive nitrogen species (RNS). Plant Gene 19:100182
Kasuga M, Miura S, Shinozaki K, Yamaguchi-Shinozaki K (2004) A combination of the Arabidopsis DREB1A gene and stress-inducible rd29A promoter improved drought-and low-temperature stress tolerance in tobacco by gene transfer. Plant Cell Physiol 45(3):346–350
Kasuga M, Liu Q, Miura S, Yamaguchi-Shinozaki K, Shinozaki K (1999) Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor. Nat Biotechnol 17(3):287–291
Kaur A, Reddy MS, Pati PK, Kumar A (2020) Over-expression of osmotin (OsmWS) gene of Withania somnifera in potato cultivar ‘Kufri Chipsona 1’imparts resistance to Alternaria solani. Plant Cell Tiss Org 142:131–142
Kim SA, Punshon T, Lanzirotti A, Li L, Alonso JM, Ecker JR et al. (2006) Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science 314(5803):1295–1298
Kim Y-H, Hong JK, Kim HS, Kwak S-S (2021) Overexpression of the sweetpotato peroxidase gene swpa4 enhances tolerance to methyl viologen-mediated oxidative stress and dehydration in Arabidopsis thaliana. J Plant Biochem Biotechnol 30(1):215–220
Kim Y-H, Kim CY, Song W-K, Park D-S, Kwon S-Y, Lee H-S et al. (2008) Overexpression of sweetpotato swpa4 peroxidase results in increased hydrogen peroxide production and enhances stress tolerance in tobacco. Planta 227(4):867–881
Kitashiba H, Ishizaka T, Isuzugawa K, Nishimura K, Suzuki T (2004) Expression of a sweet cherry DREB1/CBF ortholog in Arabidopsis confers salt and freezing tolerance. J Plant Physiol 161(10):1171–1176
Koike S, Inoue H, Mizuno D, Takahashi M, Nakanishi H, Mori S et al. (2004) OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem. Plant J 39(3):415–424
Kovtun Y, Chiu W-L, Tena G, Sheen J (2000) Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. Proc Natl Acad Sci 97(6):2940–2945
Krüger C, Berkowitz O, Stephan UW, Hell RD (2002) A metal-binding member of the late embryogenesis abundant protein family transports iron in the phloem Ofricinus communis L. J Biol Chem 277(28):25062–25069
Kumar SA, Kumari PH, Jawahar G, Prashanth S, Suravajhala P, Katam R et al. (2016) Beyond just being foot soldiers–osmotin like protein (OLP) and chitinase (Chi11) genes act as sentinels to confront salt, drought, and fungal stress tolerance in tomato. Environ Exp Bot 132:53–65
Kwon S-Y, Choi S-M, Ahn Y-O, Lee H-S, Lee H-B, Park Y-M et al. (2003) Enhanced stress-tolerance of transgenic tobacco plants expressing a human dehydroascorbate reductase gene. J Plant Physiol 160(4):347–353
Lanquar V, Lelièvre F, Bolte S, Hamès C, Alcon C, Neumann D et al. (2005) Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron. EMBO J 24(23):4041–4051
Le TT, Williams B, Mundree SG (2018) An osmotin from the resurrection plant Tripogon loliiformis (TlOsm) confers tolerance to multiple abiotic stresses in transgenic rice. Physiol Plant 162(1):13–34
Lee S-H, Ahsan N, Lee K-W, Kim D-H, Lee D-G, Kwak S-S et al. (2007) Simultaneous overexpression of both CuZn superoxide dismutase and ascorbate peroxidase in transgenic tall fescue plants confers increased tolerance to a wide range of abiotic stresses. J Plant Physiol 164(12):1626–1638
Li N, Han X, Feng D, Yuan D, Huang L-J (2019) Signaling crosstalk between salicylic acid and ethylene/jasmonate in plant defense: do we understand what they are whispering? Int J Mol Sci 20(3):671
Li R, Wu N, Fan Y, Song B (1999) Transgenic potato plants expressing osmotin gene inhibits fungal development in inoculated leaves. Chin J Biotechnol 15(2):71–75
Liang H, Lu Y, Liu H, Wang F, Xin Z, Zhang Z (2008) A novel activator-type ERF of Thinopyrum intermedium, TiERF1, positively regulates defence responses. J Exp Bot 59(11):3111–3120
Liao X, Lv C, Zhang X, Masuda T, Li M, Zhao G (2012) A novel strategy of natural plant ferritin to protect DNA from oxidative damage during iron oxidation. Free Radic Biol Med 53(2):375–382
Liu D, Raghothama KG, Hasegawa PM, Bressan RA (1994) Osmotin overexpression in potato delays development of disease symptoms. Proc Natl Acad Sci 91(5):1888–1892
Liu Q, Kasuga M, Sakuma Y, Abe H, Miura S, Yamaguchi-Shinozaki K et al. (1998) Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought-and low-temperature-responsive gene expression, respectively, in Arabidopsis. Plant Cell 10(8):1391–1406
Long L, Gao W, Xu L, Liu M, Luo X, He X et al. (2014) GbMPK3, a mitogen-activated protein kinase from cotton, enhances drought and oxidative stress tolerance in tobacco. Plant Cell, Tissue Organ Cult 116(2):153–162
Lopez-Millan A-F, Ellis DR, Grusak MA (2004) Identification and characterization of several new members of the ZIP family of metal ion transporters in Medicago truncatula. Plant Mol Biol 54(4):583–596
Lucca P, Hurrell R, Potrykus I (2001) Genetic engineering approaches to improve the bioavailability and the level of iron in rice grains. Theor Appl Genet 102(2):392–397
Luo M, Li H, Chakraborty S, Morbitzer R, Rinaldo A, Upadhyaya N et al. (2019) Efficient TALEN-mediated gene editing in wheat. Plant Biotechnol J 17(11):2026–2028
Ma J-T, Yin C-C, Zhou M-L, Wang Z-L, Wu Y-M (2015) A novel DREB transcription factor from Halimodendron halodendron leads to enhance drought and salt tolerance in Arabidopsis. Biol Plant 59(1):74–82
Mackintosh CA, Lewis J, Radmer LE, Shin S, Heinen SJ, Smith LA et al. (2007) Overexpression of defense response genes in transgenic wheat enhances resistance to Fusarium head blight. Plant Cell Rep 26(4):479–488
Mallikarjuna G, Mallikarjuna K, Reddy M, Kaul T (2011) Expression of OsDREB2A transcription factor confers enhanced dehydration and salt stress tolerance in rice (Oryza sativa L.). Biotechnol Lett 33(8):1689–1697
Matuschek E, Towo E, Svanberg U (2001) Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron. J Agric Food Chem 49(11):5630–5638
McCouch S, Baute GJ, Bradeen J, Bramel P, Bretting PK, Buckler E et al. (2013) Feeding the future. Nature 499(7456):23–24
Mira H, Martínez-García F, Peñarrubia L (2001) Evidence for the plant-specific intercellular transport of the Arabidopsis copper chaperone CCH. Plant J 25(5):521–528
Mukherjee I, Campbell NH, Ash JS, Connolly EL (2006) Expression profiling of the Arabidopsis ferric chelate reductase (FRO) gene family reveals differential regulation by iron and copper. Planta 223(6):1178–1190
Müller M, Munné-Bosch S (2015) Ethylene response factors: a key regulatory hub in hormone and stress signaling. Plant Physiol 169(1):32–41
Murray-Kolb LE, Takaiwa F, Goto F, Yoshihara T, Theil EC, Beard JL (2002) Transgenic rice is a source of iron for iron-depleted rats. J Nutr 132(5):957–960
Noori SS, Sokhansanj A (2008) Wheat plants containing an osmotin gene show enhanced ability to produce roots at high NaCl concentration. Russian J Plant Physiol 55(2):256–258
Oh SJ, Kwon CW, Choi DW, Song SI, Kim JK (2007) Expression of barley HvCBF4 enhances tolerance to abiotic stress in transgenic rice. Plant Biotechnol J 5(5):646–656
Ohme-Takagi M, Shinshi H (1995) Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7(2):173–182
Ouyang B, Chen Y, Li H, Qian C, Huang S, Ye Z (2005) Transformation of tomatoes with osmotin and chitinase genes and their resistance to Fusarium wilt. J Horticultural Sci Biotechnol 80(5):517–522
Paaby AB, Rockman MV (2013) The many faces of pleiotropy. Trends Genet 29(2):66–73
Palmgren MG, Clemens S, Williams LE, Krämer U, Borg S, Schjørring JK et al. (2008) Zinc biofortification of cereals: problems and solutions. Trends Plant Sci 13(9):464–473
Pan C, Wu X, Markel K, Malzahn AA, Kundagrami N, Sretenovic S et al. (2021) CRISPR-Act3. 0 for highly efficient multiplexed gene activation in plants. Nat Plants 7(7):1–12
Pan J, Zhang M, Kong X, Xing X, Liu Y, Zhou Y et al. (2012a) ZmMPK17, a novel maize group D MAP kinase gene, is involved in multiple stress responses. Planta 235(4):661–676
Pan Y, Seymour GB, Lu C, Hu Z, Chen X, Chen G (2012b) An ethylene response factor (ERF5) promoting adaptation to drought and salt tolerance in tomato. Plant Cell Rep. 31(2):349–360
Park JM, Park C-J, Lee S-B, Ham B-K, Shin R, Paek K-H (2001) Overexpression of the tobacco Tsi1 gene encoding an EREBP/AP2–type transcription factor enhances resistance against pathogen attack and osmotic stress in tobacco. Plant Cell 13(5):1035–1046
Parkhi V, Kumar V, Sunilkumar G, Campbell LM, Singh NK, Rathore KS (2009) Expression of apoplastically secreted tobacco osmotin in cotton confers drought tolerance. Mol Breed 23(4):625–639
Pavlović S, Savić J, Milojević J, Vinterhalter B, Girek Z, Adžić S et al. (2020) Introduction of the Nicotiana protein kinase (NPK1) gene by combining Agrobacterium-mediated transformation and recurrent somatic embryogenesis to enhance salt tolerance in cauliflower. Plant Cell, Tissue Organ Cult 143(3):635–651
Pence NS, Larsen PB, Ebbs SD, Letham DL, Lasat MM, Garvin DF et al. (2000) The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens. Proc Natl Acad Sci 97(9):4956–4960
Petit J-M, Briat J-F, Lobréaux S (2001) Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family. Biochem J 359(3):575–582
Pfeiffer WH, McClafferty B (2007) HarvestPlus: breeding crops for better nutrition. Crop Sci 47:S-88–S-105
Potrykus I (2003) Nutritionally enhanced rice to combat malnutrition disorders of the poor. Nutr Rev 61(suppl_6):S101–S104
Prashanth S, Sadhasivam V, Parida A (2008) Over expression of cytosolic copper/zinc superoxide dismutase from a mangrove plant Avicennia marina in indica rice var Pusa Basmati-1 confers abiotic stress tolerance. Transgenic Res. 17(2):281–291
Puig S, Andrés-Colás N, García-Molina A, Penarrubia L (2007) Copper and iron homeostasis in Arabidopsis: responses to metal deficiencies, interactions and biotechnological applications. Plant, Cell Environ 30(3):271–290
Qin F, Kakimoto M, Sakuma Y, Maruyama K, Osakabe Y, Tran LSP et al. (2007) Regulation and functional analysis of ZmDREB2A in response to drought and heat stresses in Zea mays L. Plant J 50(1):54–69
Raghothama K, Liu D, Nelson DE, Hasegawa PM, Bressan RA (1993) Analysis of an osmotically regulated pathogenesis-related osmotin gene promoter. Plant Mol Biol 23(6):1117–1128
Ramireddy E, Hosseini SA, Eggert K, Gillandt S, Gnad H, von Wirén N et al. (2018) Root engineering in barley: increasing cytokinin degradation produces a larger root system, mineral enrichment in the shoot and improved drought tolerance. Plant Physiol 177(3):1078–1095
Ramos MV, de Oliveira RS, Pereira HM, Moreno FB, Lobo MD, Rebelo LM et al. (2015) Crystal structure of an antifungal osmotin-like protein from Calotropis procera and its effects on Fusarium solani spores, as revealed by atomic force microscopy: Insights into the mechanism of action. Phytochemistry 119:5–18
Raney T, Pingali P (2007) Sowing a gene revolution. Sci Am 297(3):104–111
Ray DK, Mueller ND, West PC, Foley JA (2013) Yield trends are insufficient to double global crop production by 2050. PloS One 8(6):e66428
Reidmiller DR, Avery CW, Easterling DR, Kunkel KE, Lewis KL, Maycock TK et al. (2018) Impacts, risks, and adaptation in the United States: Fourth national climate assessment, volume II. (US Global Change Research Program, 2018)10.7930/NCA4.2018
Riechmann JL, Meyerowitz EM (1998) The AP2/EREBP family of plant transcription factors. Biol Chem 379:633–646
Robinson NJ, Procter CM, Connolly EL, Guerinot ML (1999) A ferric-chelate reductase for iron uptake from soils. Nature 397(6721):694–697
Roca Paixao JF, Gillet FX, Ribeiro TP, Bournaud C, Lourenco-Tessutti IT, Noriega DD et al. (2019) Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase. Sci Rep 9(1):8080
Saijo Y, Hata S, Kyozuka J, Shimamoto K, Izui K (2000) Over-expression of a single Ca2+-dependent protein kinase confers both cold and salt/drought tolerance on rice plants. Plant J 23(3):319–327
Sakuma Y, Liu Q, Dubouzet JG, Abe H, Shinozaki K, Yamaguchi-Shinozaki K (2002) DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration-and cold-inducible gene expression. Biochem Biophys Res Commun 290(3):998–1009
Sakuma Y, Maruyama K, Osakabe Y, Qin F, Seki M, Shinozaki K et al. (2006) Functional analysis of an Arabidopsis transcription factor, DREB2A, involved in drought-responsive gene expression. Plant Cell 18(5):1292–1309
Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, Von Wirén N (2004) ZmYS1 functions as a proton-coupled symporter for phytosiderophore-and nicotianamine-chelated metals. J Biol Chem 279(10):9091–9096
Scovel G, Ben-Meir H, Zuker A, Shklarman E, Ovadis M, Neta-Sharir I et al. (2000). Genetic engineering of agronomic and ornamental traits in carnation. In IV International Symposium on In Vitro Culture and Horticultural Breeding 560, pp 91–94
Seo YJ, Park J-B, Cho Y-J, Jung C, Seo HS, Park S-K et al. (2010) Overexpression of the ethylene-responsive factor gene BrERF4 from Brassica rapa increases tolerance to salt and drought in Arabidopsis plants. Molecules Cells 30(3):271–277
Sharoni AM, Nuruzzaman M, Satoh K, Shimizu T, Kondoh H, Sasaya T et al. (2011) Gene structures, classification and expression models of the AP2/EREBP transcription factor family in rice. Plant Cell Physiol 52(2):344–360
Shewry PR, Ward JL (2012) Exploiting genetic variation to improve wheat composition for the prevention of chronic diseases. Food Energy Security 1(1):47–60
Shi J, Wang H, Hazebroek J, Ertl DS, Harp T (2005) The maize low-phytic acid 3 encodes a myo-inositol kinase that plays a role in phytic acid biosynthesis in developing seeds. Plant J 42(5):708–719
Shi J, An H-L, Zhang L, Gao Z, Guo X-Q (2010) GhMPK7, a novel multiple stress-responsive cotton group C MAPK gene, has a role in broad spectrum disease resistance and plant development. Plant Mol Biol 74(1-2):1–17
Shou H, Bordallo P, Wang K (2004) Expression of the Nicotiana protein kinase (NPK1) enhanced drought tolerance in transgenic maize. J Exp Bot 55(399):1013–1019
Shuman LM (1998) Micronutrient fertilizers. J Crop Prod 1(2):165–195
Silva KJP, Brunings A, Peres NA, Mou Z, Folta KM (2015) The Arabidopsis NPR1 gene confers broad-spectrum disease resistance in strawberry. Transgenic Res 24(4):693–704
Singh B, Dheeravathu SN, Usha K (2010) Micronutrient deficiency: A global challenge and physiological approach to improve grain productivity under low zinc availability. Plant Stress 4:76–93
Singh NK, Handa AK, Hasegawa PM, Bressan RA (1985) Proteins associated with adaptation of cultured tobacco cells to NaCl. Plant Physiol 79(1):126–137
Singh NK, Bracker CA, Hasegawa PM, Handa AK, Buckel S, Hermodson MA et al. (1987) Characterization of osmotin: a thaumatin-like protein associated with osmotic adaptation in plant cells. Plant Physiol 85(2):529–536
Sokhansanj A, Noori SS, Niknam V (2006) Comparison of bacterial and plant genes participating in proline biosynthesis with osmotin gene, with respect to enhancing salinity tolerance of transgenic tobacco plants. Russian J Plant Physiol 53(1):110–115
Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW (2013) Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet 14(7):483–495
Song Z-Z, Yang S-Y, Zuo J, Su Y-H (2014) Over-expression of ApKUP3 enhances potassium nutrition and drought tolerance in transgenic rice. Biol Plant 58(4):649–658
Sripriya R, Parameswari C, Veluthambi K (2017) Enhancement of sheath blight tolerance in transgenic rice by combined expression of tobacco osmotin (ap24) and rice chitinase (chi11) genes. Vitr Cell Dev Biol-Plant 53(1):12–21
Stearns FW (2010) One hundred years of pleiotropy: a retrospective. Genetics 186(3):767–773
Sultana S, Khew C-Y, Morshed MM, Namasivayam P, Napis S, Ho C-L (2012) Overexpression of monodehydroascorbate reductase from a mangrove plant (AeMDHAR) confers salt tolerance on rice. J Plant Physiol 169(3):311–318
Sun Y, Wang C, Chen HY, Ruan H (2020) Response of plants to water stress: a meta-analysis. Front Plant Sci 11:978
Suzuki M, Takahashi M, Tsukamoto T, Watanabe S, Matsuhashi S, Yazaki J et al. (2006) Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley. Plant J 48(1):85–97
Takahashi M, Nakanishi H, Kawasaki S, Nishizawa NK, Mori S (2001) Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes. Nat Biotechnol 19(5):466–469
Tang G, Qin J, Dolnikowski GG, Russell RM, Grusak MA (2009) Golden Rice is an effective source of vitamin A. Am J Clin Nutr 89(6):1776–1783
Tang W, Charles TM, Newton RJ (2005) Overexpression of the pepper transcription factor CaPF1 in transgenic Virginia pine (Pinus virginiana Mill.) confers multiple stress tolerance and enhances organ growth. Plant Mol Biol 59(4):603–617
Tauris B, Borg S, Gregersen PL, Holm PB (2009) A roadmap for zinc trafficking in the developing barley grain based on laser capture microdissection and gene expression profiling. J Exp Bot 60(4):1333–1347
Teige M, Scheikl E, Eulgem T, Dóczi R, Ichimura K, Shinozaki K et al. (2004) The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. Mol Cell 15(1):141–152
Trujillo L, Sotolongo M, Menendez C, Ochogavia M, Coll Y, Hernandez I et al. (2008) SodERF3, a novel sugarcane ethylene responsive factor (ERF), enhances salt and drought tolerance when overexpressed in tobacco plants. Plant Cell Physiol 49(4):512–525
Ushimaru T, Nakagawa T, Fujioka Y, Daicho K, Naito M, Yamauchi Y et al. (2006) Transgenic Arabidopsis plants expressing the rice dehydroascorbate reductase gene are resistant to salt stress. J Plant Physiol 163(11):1179–1184
Vasconcelos M, Datta K, Oliva N, Khalekuzzaman M, Torrizo L, Krishnan S et al. (2003) Enhanced iron and zinc accumulation in transgenic rice with the ferritin gene. Plant Sci 164(3):371–378
Vert G, Grotz N, Dédaldéchamp F, Gaymard F, Guerinot ML, Briat J-F et al. (2002) IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth. Plant Cell 14(6):1223–1233
Viktorova J, Krasny L, Kamlar M, Novakova M, Mackova M, Macek T (2012) Osmotin, a pathogenesis-related protein. Curr Protein Pept Sci 13(7):672–681
Wagner GP, Zhang J (2011) The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms. Nat Rev Genet 12(3):204–213
Wang C-T, Ru J-N, Liu Y-W, Li M, Zhao D, Yang J-F et al. (2018) Maize WRKY transcription factor ZmWRKY106 confers drought and heat tolerance in transgenic plants. Int J Mol Sci 19(10):3046
Wang H, Wang H, Shao H, Tang X (2016) Recent advances in utilizing transcription factors to improve plant abiotic stress tolerance by transgenic technology. Front Plant Sci 7:67
Wang H, Huang Z, Chen Q, Zhang Z, Zhang H, Wu Y et al. (2004) Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance. Plant Mol Biol 55(2):183–192
Wang L, Qin L, Liu W, Zhang D, Wang Y (2014) A novel ethylene-responsive factor from Tamarix hispida, ThERF1, is a GCC-box-and DRE-motif binding protein that negatively modulates abiotic stress tolerance in Arabidopsis. Physiol Plant 152(1):84–97
Wang Y, Wisniewski M, Meilan R, Cui M, Webb R, Fuchigami L (2005) Overexpression of cytosolic ascorbate peroxidase in tomato confers tolerance to chilling and salt stress. J Am Soc Horticultural Sci 130(2):167–173
Wang Y, Wisniewski M, Meilan R, Cui M, Fuchigami L (2006) Transgenic tomato (Lycopersicon esculentum) overexpressing cAPX exhibits enhanced tolerance to UV-B and heat stress.
Waters BM, Grusak MA (2008) Whole-plant mineral partitioning throughout the life cycle in Arabidopsis thaliana ecotypes Columbia, Landsberg erecta, Cape Verde Islands, and the mutant line ysl1ysl3. N. Phytologist 177(2):389–405
White PJ, Broadley MR (2005) Biofortifying crops with essential mineral elements. Trends Plant Sci 10(12):586–593
White PJ, Broadley MR (2009) Biofortification of crops with seven mineral elements often lacking in human diets–iron, zinc, copper, calcium, magnesium, selenium and iodine. N. Phytologist 182(1):49–84
White PJ, Bowen HC, Demidchik V, Nichols C, Davies JM (2002) Genes for calcium-permeable channels in the plasma membrane of plant root cells. Biochim et Biophys Acta 1564(2):299–309
Wintz H, Fox T, Wu Y-Y, Feng V, Chen W, Chang H-S et al. (2003) Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis. J Biol Chem 278(48):47644–47653
von Wirén N, Marschner H, Römheld V (1995) Uptake kinetics of iron-phytosiderophores in two maize genotypes differing in iron efficiency. Physiol Plant 93(4):611–616
von Wirén N, Marschner H, Romheld V (1996) Roots of iron-efficient maize also absorb phytosiderophore-chelated zinc. Plant Physiol 111(4):1119–1125
Wirth J, Poletti S, Aeschlimann B, Yakandawala N, Drosse B, Osorio S et al. (2009) Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin. Plant Biotechnol J 7(7):631–644
Wong CKE, Cobbett CS (2009) HMA P-type ATPases are the major mechanism for root-to-shoot Cd translocation in Arabidopsis thaliana. N. Phytologist 181(1):71–78
Wu H, Li L, Du J, Yuan Y, Cheng X, Ling H-Q (2005) Molecular and biochemical characterization of the Fe (III) chelate reductase gene family in Arabidopsis thaliana. Plant Cell Physiol 46(9):1505–1514
Wu L, Zhang Z, Zhang H, Wang X-C, Huang R (2008) Transcriptional modulation of ethylene response factor protein JERF3 in the oxidative stress response enhances tolerance of tobacco seedlings to salt, drought, and freezing. Plant Physiol 148(4):1953–1963
Xianghong Li et al. Cas-CLOVER™: A High-Fidelity Genome Editing System for Safe and Efficient Modification of Cells for Immunotherapy. 2018 Precision CRISPR Congress Poster Presentation, Boston, MA
Xiong L, Yang Y (2003) Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid–inducible mitogen-activated protein kinase. Plant Cell 15(3):745–759
Xu J, Yang J, Duan X, Jiang Y, Zhang P (2014) Increased expression of native cytosolic Cu/Zn superoxide dismutase and ascorbate peroxidase improves tolerance to oxidative and chilling stresses in cassava (Manihot esculenta Crantz). BMC Plant Biol 14(1):1–14
Xu Z-S, Xia L-Q, Chen M, Cheng X-G, Zhang R-Y, Li L-C et al. (2007) Isolation and molecular characterization of the Triticum aestivum L. ethylene-responsive factor 1 (TaERF1) that increases multiple stress tolerance. Plant Mol Biol 65(6):719–732
Xue X, Cao Z, Zhang X, Wang Y, Zhang Y, Chen Z et al. (2016) Overexpression of OsOSM1 enhances resistance to rice sheath blight. Plant Dis 100(8):1634–1642
Yan H, Jia H, Chen X, Hao L, An H, Guo X (2014) The cotton WRKY transcription factor GhWRKY17 functions in drought and salt stress in transgenic Nicotiana benthamiana through ABA signaling and the modulation of reactive oxygen species production. Plant Cell Physiol 55(12):2060–2076
Yang R, Liu J, Lin Z, Sun W, Wu Z, Hu H et al. (2018) ERF transcription factors involved in salt response in tomato. Plant Growth Regul 84(3):573–582
Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P et al. (2000) Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287(5451):303–305
Yin L, Mano JI, Tanaka K, Wang S, Zhang M, Deng X et al. (2017) High level of reduced glutathione contributes to detoxification of lipid peroxide-derived reactive carbonyl species in transgenic Arabidopsis overexpressing glutathione reductase under aluminum stress. Physiol Plant 161(2):211–223
Ying Z, Shuli S, Wei S, Yan Z, Jun Z, Weiwei R, Chuang Z (2017) Overexpression of soybean GmERF9 enhances the tolerance to drought and cold in the transgenic tobacco. Plant Cell Tissue and Organ Culture (PCTOC) 128(3):607–618. https://doi.org/10.1007/s11240-016-1137-8
Yoshimura K, Miyao K, Gaber A, Takeda T, Kanaboshi H, Miyasaka H et al. (2004) Enhancement of stress tolerance in transgenic tobacco plants overexpressing Chlamydomonas glutathione peroxidase in chloroplasts or cytosol. Plant J 37(1):21–33
Youm JW, Jeon JH, Choi D, Yi SY, Joung H, Kim HS (2008) Ectopic expression of pepper CaPF1 in potato enhances multiple stresses tolerance and delays initiation of in vitro tuberization. Planta 228(4):701–708
Zafar SA, Zaidi SS-E-A, Gaba Y, Singla-Pareek SL, Dhankher OP, Li X et al. (2020) Engineering abiotic stress tolerance via CRISPR/Cas-mediated genome editing. J Exp Bot 71(2):470–479
Zeigler RS (2007) Rice and the millennium development goals: the International Rice Research Institute’s strategic plan 2007–2015. Paddy and Water Environment 5(2):67–71
Zhang G, Chen M, Li L, Xu Z, Chen X, Guo J et al. (2009) Overexpression of the soybean GmERF3 gene, an AP2/ERF type transcription factor for increased tolerances to salt, drought, and diseases in transgenic tobacco. J Exp Bot 60(13):3781–3796
Zhang L, Sun L, Zhang L, Qiu H, Liu C, Wang A et al. (2017) A Cu/Zn superoxide dismutase gene from Saussurea involucrata Kar. & Kir., SiCSD, enhances drought, cold, and oxidative stress in transgenic tobacco. Can J Plant Sci 97(5):816–826
Zhang X, Liu S, Takano T (2008) Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold tolerance. Plant Mol Biol 68(1):131–143
Zhu B, Chen TH, Li PH (1993) Expression of an ABA-responsive osmotin-like gene during the induction of freezing tolerance in Solanum commersonii. Plant Mol Biol 21(4):729–735
https://www.nature.com/articles/s41437-022-00500-w High-value pleiotropic genes for developing multiple stress-tolerant biofortified crops for 21st-century challenges
